- Abstract:
-
In neuronal synapses, neurotransmitter-loaded vesicles fuse with presynaptic plasma membrane in a complex sequence of tightly regulated events. The assembly of specialized SNARE complexes plays a pivotal role in this process. The function of the chaperone cysteine string protein α (CSPα) is important for synaptic SNARE complex formation, and mice lacking this protein develop severe synaptic dysfunction and neurodegeneration that lead to their death within 3 months after birth. Another presyna...
Expand abstract - Publisher copy:
- 10.1074/jbc.m112.422402
-
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- Journal:
- The Journal of biological chemistry
- Volume:
- 287
- Issue:
- 53
- Pages:
- 44471-44477
- Publication date:
- 2012-12-05
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- URN:
-
uuid:aaed4fa3-4cb8-43bd-82a9-1dfa4169c323
- Source identifiers:
-
492370
- Local pid:
- pubs:492370
- Language:
- English
- Keywords:
- Copyright date:
- 2012
Journal article
Contrasting effects of α-synuclein and γ-synuclein on the phenotype of cysteine string protein α (CSPα) null mutant mice suggest distinct function of these proteins in neuronal synapses.
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