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Contrasting effects of α-synuclein and γ-synuclein on the phenotype of cysteine string protein α (CSPα) null mutant mice suggest distinct function of these proteins in neuronal synapses.

Abstract:

In neuronal synapses, neurotransmitter-loaded vesicles fuse with presynaptic plasma membrane in a complex sequence of tightly regulated events. The assembly of specialized SNARE complexes plays a pivotal role in this process. The function of the chaperone cysteine string protein α (CSPα) is important for synaptic SNARE complex formation, and mice lacking this protein develop severe synaptic dysfunction and neurodegeneration that lead to their death within 3 months after birth. Another presyna...

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Publisher copy:
10.1074/jbc.m112.422402

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Journal:
The Journal of biological chemistry
Volume:
287
Issue:
53
Pages:
44471-44477
Publication date:
2012-12-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:aaed4fa3-4cb8-43bd-82a9-1dfa4169c323
Source identifiers:
492370
Local pid:
pubs:492370

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