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Journal article

In-depth quantitative cardiac proteomics combining electron transfer dissociation and the metalloendopeptidase Lys-N with the SILAC mouse.

Abstract:

In quantitative proteomics stable isotope labeling has progressed from cultured cells toward the total incorporation of labeled atoms or amino acids into whole multicellular organisms. For instance, the recently introduced (13)C(6)-lysine labeled SILAC mouse allows accurate comparison of protein expression directly in tissue. In this model, only lysine, but not arginine, residues are isotope labeled, as the latter may cause complications to the quantification by in vivo conversion of arginine...

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Publication status:
Published

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Publisher copy:
10.1074/mcp.o111.008474

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Physical and Theoretical Chem
Role:
Author
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Journal:
Molecular and cellular proteomics : MCP
Volume:
10
Issue:
10
Pages:
O111.008474
Publication date:
2011-10-05
DOI:
EISSN:
1535-9484
ISSN:
1535-9476
URN:
uuid:aaecf05b-4cc2-40c9-a7c9-42b43580e6b9
Source identifiers:
384565
Local pid:
pubs:384565

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