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Insights into the evolution of a complex virus from the crystal structure of vaccinia virus D13.

Abstract:

The morphogenesis of poxviruses such as vaccinia virus (VACV) sees the virion shape mature from spherical to brick-shaped. Trimeric capsomers of the VACV D13 protein form a transitory, stabilizing lattice on the surface of the initial spherical immature virus particle. The crystal structure of D13 reveals that this major scaffolding protein comprises a double β barrel "jelly-roll" subunit arranged as pseudo-hexagonal trimers. These structural features are characteristic of the major capsid pr...

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Publication status:
Published

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Publisher copy:
10.1016/j.str.2011.03.023

Authors


Graham, SC More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
Journal:
Structure (London, England : 1993)
Volume:
19
Issue:
7
Pages:
1011-1020
Publication date:
2011-07-05
DOI:
EISSN:
1878-4186
ISSN:
0969-2126
URN:
uuid:aaece297-bfaa-4086-a052-b30944b88ecb
Source identifiers:
166436
Local pid:
pubs:166436

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