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Quasispecies heterogeneity within the E1/E2 region as a pretreatment variable during pegylated interferon therapy of chronic hepatitis C virus infection.

Abstract:

A series of 29 patients undergoing treatment for chronic hepatitis C virus (HCV) genotype 1 infection with pegylated alpha-2a interferon plus ribavirin were studied for patterns of response to antiviral therapy and viral quasispecies evolution. All patients were treatment naive and had chronic inflammation and fibrosis on biopsy. As part of an analysis of pretreatment variables that might affect the outcome of treatment, genetic heterogeneity within the viral E1-E2 glycoprotein region (nucleo...

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Authors


Chambers, TJ More by this author
Hembrador, E More by this author
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Journal:
Journal of virology
Volume:
79
Issue:
5
Pages:
3071-3083
Publication date:
2005-03-29
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:aaeb58f3-cddc-4936-9a4a-726fb1f3cbe3
Source identifiers:
426419
Local pid:
pubs:426419

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