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Journal article

Tryptophan degradation by human placental indoleamine 2,3-dioxygenase regulates lymphocyte proliferation.

Abstract:

1. The physiological importance of human placental indoleamine 2,3-dioxygenase (EC 1.13.11.42), the first and rate-limiting enzyme in tryptophan metabolism, in regulating feto-maternal immunology has been studied. 2. Concentrations were measured in placental villous explant conditioned media of 14 amino acids that are known to be required for lymphocyte proliferation. In the absence of interferon-gamma only tryptophan and threonine were significantly lowered; in the presence of interferon-gam...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Women's and Reproductive Health
Role:
Author
Journal:
Journal of physiology More from this journal
Volume:
535
Issue:
Pt 1
Pages:
207-215
Publication date:
2001-08-01
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
Language:
English
Keywords:
Pubs id:
pubs:114068
UUID:
uuid:aae942f3-764b-4182-8a0b-a7d1bd68e5ae
Local pid:
pubs:114068
Source identifiers:
114068
Deposit date:
2013-11-16

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