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Tryptophan degradation by human placental indoleamine 2,3-dioxygenase regulates lymphocyte proliferation.

Abstract:

1. The physiological importance of human placental indoleamine 2,3-dioxygenase (EC 1.13.11.42), the first and rate-limiting enzyme in tryptophan metabolism, in regulating feto-maternal immunology has been studied. 2. Concentrations were measured in placental villous explant conditioned media of 14 amino acids that are known to be required for lymphocyte proliferation. In the absence of interferon-gamma only tryptophan and threonine were significantly lowered; in the presence of interferon-gam...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Obstetrics and Gynaecology
Redman, CW More by this author
Journal:
The Journal of physiology
Volume:
535
Issue:
Pt 1
Pages:
207-215
Publication date:
2001-08-05
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
URN:
uuid:aae942f3-764b-4182-8a0b-a7d1bd68e5ae
Source identifiers:
114068
Local pid:
pubs:114068

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