Tryptophan degradation by human placental indoleamine 2,3-dioxygenase regulates lymphocyte proliferation.
1. The physiological importance of human placental indoleamine 2,3-dioxygenase (EC 188.8.131.52), the first and rate-limiting enzyme in tryptophan metabolism, in regulating feto-maternal immunology has been studied. 2. Concentrations were measured in placental villous explant conditioned media of 14 amino acids that are known to be required for lymphocyte proliferation. In the absence of interferon-gamma only tryptophan and threonine were significantly lowered; in the presence of interferon-gam...Expand abstract
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