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A calibration method for quantitative BOLD fMRI based on hyperoxia.

Abstract:

The estimation of changes in CMR(O2) using functional MRI involves an essential calibration step using a vasoactive agent to induce an isometabolic change in CBF. This calibration procedure is performed most commonly using hypercapnia as the isometabolic stimulus. However, hypercapnia possesses a number of detrimental side effects. Here, a new method is presented using hyperoxia to perform the same calibration step. This procedure requires independent measurement of Pa(O2), the BOLD signal, a...

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Publication status:
Published

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Authors


Chiarelli, PA More by this author
Gallichan, D More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Journal:
NeuroImage
Volume:
37
Issue:
3
Pages:
808-820
Publication date:
2007-09-05
DOI:
EISSN:
1095-9572
ISSN:
1053-8119
URN:
uuid:aae75d8a-2204-49a8-878c-99af2382ade5
Source identifiers:
241478
Local pid:
pubs:241478

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