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A linear complexity phasing method for thousands of genomes.

Abstract:
Human-disease etiology can be better understood with phase information about diploid sequences. We present a method for estimating haplotypes, using genotype data from unrelated samples or small nuclear families, that leads to improved accuracy and speed compared to several widely used methods. The method, segmented haplotype estimation and imputation tool (SHAPEIT), scales linearly with the number of haplotypes used in each iteration and can be run efficiently on whole chromosomes.
Publication status:
Published

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Publisher copy:
10.1038/nmeth.1785

Authors


Delaneau, O More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Statistics, Clinical Medicine
Zagury, JF More by this author
Journal:
Nature methods
Volume:
9
Issue:
2
Pages:
179-181
Publication date:
2012-02-05
DOI:
EISSN:
1548-7105
ISSN:
1548-7091
URN:
uuid:aae12844-98df-41a9-a1ad-ba077a1edcea
Source identifiers:
216130
Local pid:
pubs:216130
Language:
English
Keywords:

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