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Coexpression network analysis in abdominal and gluteal adipose tissue reveals regulatory genetic loci for metabolic syndrome and related phenotypes.

Abstract:

Metabolic Syndrome (MetS) is highly prevalent and has considerable public health impact, but its underlying genetic factors remain elusive. To identify gene networks involved in MetS, we conducted whole-genome expression and genotype profiling on abdominal (ABD) and gluteal (GLU) adipose tissue, and whole blood (WB), from 29 MetS cases and 44 controls. Co-expression network analysis for each tissue independently identified nine, six, and zero MetS-associated modules of coexpressed genes in AB...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pgen.1002505

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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Statistics
Role:
Author
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Funding agency for:
Holmes, CC
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Funding agency for:
McCarthy, MI
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Funding agency for:
Lindgren, CM
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Funding agency for:
Zondervan, KT
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS genetics Journal website
Volume:
8
Issue:
2
Pages:
Article: e1002505
Publication date:
2012-01-01
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
URN:
uuid:aae03bfd-de09-4542-a2f7-8a340d027533
Source identifiers:
313015
Local pid:
pubs:313015

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