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Journal article

Molecular and functional sex differences of noradrenergic neurons in the mouse locus coeruleus

Abstract:

Preclinical work has long focused on male animals, though biological sex clearly influences risk for certain diseases, including many psychiatric disorders. Such disorders are often treated by drugs targeting the CNS norepinephrine system. Despite roles for noradrenergic neurons in behavior and neuropsychiatric disease models, their molecular characterization has lagged. We profiled mouse noradrenergic neurons in vivo, defining over 3,000 high-confidence transcripts expressed therein, includi...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.celrep.2018.04.054

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Ludwig Institute
Role:
Author
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Simons Foundation More from this funder
Brain and Behavior Research Foundation More from this funder
Ludwig Cancer Research More from this funder
Washington University More from this funder
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Publisher:
Elsevier Publisher's website
Journal:
Cell Reports Journal website
Volume:
23
Issue:
8
Pages:
2225-2235
Publication date:
2018-05-22
Acceptance date:
2018-04-13
DOI:
EISSN:
2211-1247
ISSN:
2211-1247
Pubs id:
pubs:854553
URN:
uri:aad707d1-33d7-4795-bbf0-7b6703ab8d1a
UUID:
uuid:aad707d1-33d7-4795-bbf0-7b6703ab8d1a
Local pid:
pubs:854553

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