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Molecular and functional sex differences of noradrenergic neurons in the mouse locus coeruleus

Abstract:

Preclinical work has long focused on male animals, though biological sex clearly influences risk for certain diseases, including many psychiatric disorders. Such disorders are often treated by drugs targeting the CNS norepinephrine system. Despite roles for noradrenergic neurons in behavior and neuropsychiatric disease models, their molecular characterization has lagged. We profiled mouse noradrenergic neurons in vivo, defining over 3,000 high-confidence transcripts expressed therein, includi...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
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Name:
National Institutes of Health
Grant:
R01NS095809
More from this funder
Name:
Biotechnology and Biological Sciences Research Council
Grant:
BB/M001873/1
More from this funder
Name:
Brain and Behavior Research Foundation
Publisher:
Elsevier
Journal:
Cell Reports More from this journal
Volume:
23
Issue:
8
Pages:
2225-2235
Publication date:
2018-05-22
Acceptance date:
2018-04-13
DOI:
EISSN:
2211-1247
ISSN:
2211-1247
Pmid:
29791834
Language:
English
Keywords:
Pubs id:
pubs:854553
UUID:
uuid:aad707d1-33d7-4795-bbf0-7b6703ab8d1a
Local pid:
pubs:854553
Source identifiers:
854553
Deposit date:
2018-06-06

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