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Embryonic progenitor pools generate diversity in fine-scale excitatory cortical subnetworks

Abstract:

The mammalian neocortex is characterized by a variety of neuronal cell types and precise arrangements of synaptic connections, but the processes that generate this diversity are poorly understood. Here we examine how a pool of embryonic progenitor cells consisting of apical intermediate progenitors (aIPs) contribute to diversity within the upper layers of mouse cortex. In utero labeling combined with single-cell RNA-sequencing reveals that aIPs can generate transcriptionally defined glutamate...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-019-13206-1

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
ORCID:
0000-0001-9787-3307
More by this author
Role:
Author
ORCID:
0000-0001-6604-0257
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
Role:
Author
ORCID:
0000-0002-9218-6927
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
ORCID:
0000-0003-0146-1821
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Experimental Psychology
Role:
Author
Publisher:
Nature Research
Journal:
Nature Communications More from this journal
Volume:
10
Article number:
5224
Publication date:
2019-11-19
Acceptance date:
2019-10-28
DOI:
EISSN:
2041-1723
Language:
English
Keywords:
Pubs id:
pubs:1072719
UUID:
uuid:aad658e3-6580-491c-ab53-4fe783cfe54b
Local pid:
pubs:1072719
Source identifiers:
1072719
Deposit date:
2019-11-21

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