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Thesis

Identification and functional analysis of single nucleotide polymorphisms that affect human cancer

Abstract:

Aims: The p53 regulatory network is crucial in directing the suppression of cancer formation and mediating the response to commonly used cancer therapies. Functional genetic variants in the genes comprising this network could help identify individuals at greater risk for cancer and patients with poorer responses to therapies, but few such variants have been identified as yet. Methods: We first develop and apply three different screens that utilize known characteristics of functional single nu...

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Institution:
University of Oxford
Research group:
Ludwig Institute for Cancer Research
Oxford college:
Hertford College
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of
Role:
Author

Contributors

Role:
Supervisor
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:aacc7084-81a8-4e97-b1ac-024d9bed106e
Local pid:
ora:8718

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