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Journal article

Assessment of cone survival in response to CNTF, GDNF, and VEGF165b in a novel ex vivo model of end-stage retinitis pigmentosa.

Abstract:

PURPOSE: To develop a robust ex vivo model for evaluating cone survival in end-stage retinitis pigmentosa (RP) and apply this to quantify the effects of putative neuroprotective compounds. METHODS: Rhodopsin knockout mice were crossed with OPN1-GFP reporter mice so that GFP-positive cones could be identified against the background of a rod-specific degeneration. Retinal explants were harvested from 10-week-old mice and maintained in organotypic culture. Ciliary neurotrophic factor (CNTF), gl...

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Publication status:
Published

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Publisher copy:
10.1167/iovs.11-7996

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Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Sub department:
Institute of Biomedical Engineering
Role:
Author
Journal:
Investigative ophthalmology and visual science
Volume:
52
Issue:
10
Pages:
7340-7346
Publication date:
2011-09-01
DOI:
EISSN:
1552-5783
ISSN:
0146-0404
Source identifiers:
172115

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