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Assessment of cone survival in response to CNTF, GDNF, and VEGF165b in a novel ex vivo model of end-stage retinitis pigmentosa.

Abstract:

PURPOSE: To develop a robust ex vivo model for evaluating cone survival in end-stage retinitis pigmentosa (RP) and apply this to quantify the effects of putative neuroprotective compounds. METHODS: Rhodopsin knockout mice were crossed with OPN1-GFP reporter mice so that GFP-positive cones could be identified against the background of a rod-specific degeneration. Retinal explants were harvested from 10-week-old mice and maintained in organotypic culture. Ciliary neurotrophic factor (CNTF), gl...

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Publication status:
Published

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Publisher copy:
10.1167/iovs.11-7996

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience, Biomedical Research Centre
Role:
Author
Journal:
Investigative ophthalmology and visual science
Volume:
52
Issue:
10
Pages:
7340-7346
Publication date:
2011-09-05
DOI:
EISSN:
1552-5783
ISSN:
0146-0404
URN:
uuid:aac2f71a-4d6e-432a-912f-2007a2f3a884
Source identifiers:
172115
Local pid:
pubs:172115

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