- Abstract:
-
PURPOSE: To develop a robust ex vivo model for evaluating cone survival in end-stage retinitis pigmentosa (RP) and apply this to quantify the effects of putative neuroprotective compounds. METHODS: Rhodopsin knockout mice were crossed with OPN1-GFP reporter mice so that GFP-positive cones could be identified against the background of a rod-specific degeneration. Retinal explants were harvested from 10-week-old mice and maintained in organotypic culture. Ciliary neurotrophic factor (CNTF), gl...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1167/iovs.11-7996
-
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- Journal:
- Investigative ophthalmology and visual science
- Volume:
- 52
- Issue:
- 10
- Pages:
- 7340-7346
- Publication date:
- 2011-09-05
- DOI:
- EISSN:
-
1552-5783
- ISSN:
-
0146-0404
- URN:
-
uuid:aac2f71a-4d6e-432a-912f-2007a2f3a884
- Source identifiers:
-
172115
- Local pid:
- pubs:172115
- Language:
- English
- Keywords:
- Copyright date:
- 2011
Journal article
Assessment of cone survival in response to CNTF, GDNF, and VEGF165b in a novel ex vivo model of end-stage retinitis pigmentosa.
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