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Patterns in metabolite profile are associated with risk of more aggressive prostate cancer: A prospective study of 3,057 matched case–control sets from EPIC

Abstract:

Metabolomics may reveal novel insights into the etiology of prostate cancer, for which few risk factors are established. We investigated the association between patterns in baseline plasma metabolite profile and subsequent prostate cancer risk, using data from 3,057 matched case–control sets from the European Prospective Investigation into Cancer and Nutrition (EPIC). We measured 119 metabolite concentrations in plasma samples, collected on average 9.4 years before diagnosis, by mass spectrom...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/ijc.32314

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Cancer Epidemiology Unit
Role:
Author
ORCID:
0000-0002-7733-8750
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Role:
Author
ORCID:
0000-0002-6846-1204
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Publisher:
Wiley Publisher's website
Journal:
International Journal of Cancer Journal website
Volume:
146
Issue:
3
Pages:
720-730
Publication date:
2019-04-29
Acceptance date:
2019-03-19
DOI:
EISSN:
1097-0215
ISSN:
0020-7136
Pmid:
30951192
Source identifiers:
991912
Language:
English
Keywords:
Pubs id:
pubs:991912
UUID:
uuid:aac124c6-9ec4-4cd7-91e2-c8541f607fba
Local pid:
pubs:991912
Deposit date:
2019-04-24

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