Two-photon photodynamic therapy and its potential application to age related macular degeneration

Journal article

Photodynamic therapy (PDT) using verteporfin is widely used for treatment of age related macular degeneration (AMD). Due to non-perfect selectivity of the drug accumulation in the neovasculature some collateral damage to healthy tissue arises during the treatment. Damage to healthy structures in the eye is always a concern because of a high probability of reducing visual acuity. Two-photon (2-γ) photodynamic therapy potentially offers much higher treatment selectivity than its one-photon (1-γ...

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Authors: Karotki, A; Khurana, M; Bisland, S; Moriyama, E; Simpson, E

• Journal: Progress in Biomedical Optics and Imaging - Proceedings of SPIE
• Volume: 6427
• Publication date: 2007-01-01
• DOI: 10.1117/12.701086
• ISSN: 1605-7422
• Language: English
• Keywords: Verteporfin; Two-photon absorption; YPEN-1; Window chamber model; Porphyrin dimer; Chlorin e6; Photodynamic therapy; Endothelium; Aluminum phthalocyanine; Macular degeneration