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A gene variant near ATM is significantly associated with metformin treatment response in type 2 diabetes: a replication and meta-analysis of five cohorts.

Abstract:

AIMS/HYPOTHESIS: In this study we aimed to replicate the previously reported association between the glycaemic response to metformin and the SNP rs11212617 at a locus that includes the ataxia telangiectasia mutated (ATM) gene in multiple additional populations. METHODS: Incident users of metformin selected from the Diabetes Care System West-Friesland (DCS, n = 929) and the Rotterdam Study (n = 182) from the Netherlands, and the CARDS Trial (n = 254) from the UK were genotyped for rs11212617 a...

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Publication status:
Published

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Publisher copy:
10.1007/s00125-012-2537-x

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Journal:
Diabetologia
Volume:
55
Issue:
7
Pages:
1971-1977
Publication date:
2012-07-05
DOI:
EISSN:
1432-0428
ISSN:
0012-186X
URN:
uuid:aabc02c0-8875-49b5-83a2-05a55c8e8872
Source identifiers:
342032
Local pid:
pubs:342032

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