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Characterization of multiple nuclear localization signals in herpes simplex virus type 1 thymidine kinase.

Abstract:

We have reported previously that the herpes simplex virus type 1 (HSV-1) thymidine kinase (TK) fused with green fluorescent protein (GFP) is localized in the nucleus of HSV-1 TK-GFP gene-transfected cells (Degrève et al. (1998) J. Virol. 72, 9535-9543). Deletion of the N-terminal 34 amino acids or selective mutation of the nonapeptide (25)RRTALRPRR(33), located in the N-terminal region of HSV-1 TK, resulted in the loss of the specific nuclear localization of HSV-1 TK. Utilizing information on...

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Publication status:
Published

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Publisher copy:
10.1006/bbrc.1999.1485

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Journal:
Biochemical and biophysical research communications
Volume:
264
Issue:
2
Pages:
338-342
Publication date:
1999-10-05
DOI:
EISSN:
1090-2104
ISSN:
0006-291X
URN:
uuid:aaae5b91-86ed-417f-8a2a-92ae0e918889
Source identifiers:
28223
Local pid:
pubs:28223

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