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Measurement of replication structures at the nanometer scale using super-resolution light microscopy.

Abstract:

DNA replication, similar to other cellular processes, occurs within dynamic macromolecular structures. Any comprehensive understanding ultimately requires quantitative data to establish and test models of genome duplication. We used two different super-resolution light microscopy techniques to directly measure and compare the size and numbers of replication foci in mammalian cells. This analysis showed that replication foci vary in size from 210 nm down to 40 nm. Remarkably, spatially modulat...

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Publisher copy:
10.1093/nar/gkp901

Authors


Baddeley, D More by this author
Chagin, VO More by this author
Schermelleh, L More by this author
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Journal:
Nucleic acids research
Volume:
38
Issue:
2
Pages:
e8
Publication date:
2010-01-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:aaa828c8-be5f-4e65-88f4-e6451f3d5ffd
Source identifiers:
310395
Local pid:
pubs:310395

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