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Impaired cAMP-cGMP cross-talk during cardiac sympathetic dysautonomia.

Abstract:

Dysautonomia is a well-established contributor to the development and progression of hypertension and many other cardiovascular diseases. Sympathetic hyperactivity and vagal impairment are features of human hypertension, as well as in subjects with a familial predisposition for hypertension. This neural phenotype is also observed in the spontaneously hypertensive rat (SHR)3. Moreover, it is widely accepted that autonomic imbalance contributes to the pathogenesis of hypertension itself, where...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1080/19336950.2016.1259040

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Department:
Oxford, MSD, Physiology Anatomy and Genetics
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Department:
Oxford, MSD, Physiology Anatomy and Genetics
More by this author
Department:
Merton College
Publisher:
Taylor & Francis Publisher's website
Journal:
Channels Journal website
Volume:
11
Issue:
3
Pages:
178-180
Publication date:
2016-11-05
Acceptance date:
2016-11-04
DOI:
EISSN:
1933-6969
ISSN:
1933-6950
Pubs id:
pubs:661748
URN:
uri:aaa7dfe5-d445-4a2d-b8bd-6b3ec5c4fa94
UUID:
uuid:aaa7dfe5-d445-4a2d-b8bd-6b3ec5c4fa94
Local pid:
pubs:661748

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