An investigation into the interaction of dopamine and glutamate in behaviours relevant to schizophrenia

Thesis

Aberrant dopaminergic activity is widely believed to underlie at least some of the symptoms seen in schizophrenia. This belief is partly based on all currently used antipsychotics antagonising the dopaminergic D2 receptor. However, there is less agreement on what causes this aberrant dopamine activity. One candidate is a glutamatergic change upstream of the dopamine system. I investigated this glutamate theory of schizophrenia by examining the effect of glutamatergic manipulations on the d...

Expand abstract

Authors: Boerner, T

• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: Dopamine; Glutamate; Schizophrenia
• Subjects: Behavioural Neuroscience; Neuropsychopharmacology