Journal article
Mechanism of Lys48-linked polyubiquitin chain recognition by the Mud1 UBA domain.
- Abstract:
-
The ubiquitin-pathway associated (UBA) domain is a 40-residue polyubiquitin-binding motif. The Schizosaccharomyces pombe protein Mud1 is an ortholog of the Saccharomyces cerevisiae DNA-damage response protein Ddi1 and binds to K48-linked polyubiquitin through its UBA domain. We have solved the crystal structure of Mud1 UBA at 1.8 angstroms resolution, revealing a canonical three-helical UBA fold. We have probed the interactions of this domain using mutagenesis, surface plasmon resonance, NMR ...
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- Publication status:
- Published
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- Publisher copy:
- 10.1038/sj.emboj.7600797
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Authors
Bibliographic Details
- Journal:
- EMBO journal
- Volume:
- 24
- Issue:
- 18
- Pages:
- 3178-3189
- Publication date:
- 2005-09-01
- DOI:
- EISSN:
-
1460-2075
- ISSN:
-
0261-4189
- Source identifiers:
-
6781
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:6781
- UUID:
-
uuid:aa9c46f7-fa3c-4bc1-887e-39c3fc1c6766
- Local pid:
- pubs:6781
- Deposit date:
- 2013-11-16
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- Copyright date:
- 2005
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