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Mechanism of Lys48-linked polyubiquitin chain recognition by the Mud1 UBA domain.

Abstract:

The ubiquitin-pathway associated (UBA) domain is a 40-residue polyubiquitin-binding motif. The Schizosaccharomyces pombe protein Mud1 is an ortholog of the Saccharomyces cerevisiae DNA-damage response protein Ddi1 and binds to K48-linked polyubiquitin through its UBA domain. We have solved the crystal structure of Mud1 UBA at 1.8 angstroms resolution, revealing a canonical three-helical UBA fold. We have probed the interactions of this domain using mutagenesis, surface plasmon resonance, NMR ...

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Publication status:
Published

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Publisher copy:
10.1038/sj.emboj.7600797

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
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Journal:
EMBO journal
Volume:
24
Issue:
18
Pages:
3178-3189
Publication date:
2005-09-01
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
Source identifiers:
6781

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