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The locus coeruleus in schizophrenia: a postmortem study of noradrenergic neurones.

Abstract:

Despite evidence for an abnormality of noradrenergic function in schizophrenia, it remains unclear whether the number of noradrenergic neurones is normal in patients with the disorder. In postmortem, formalin-fixed tissue from 15 schizophrenic patients and 18 controls matched for age and gender, we made estimates of the number and size of tyrosine-hydroxylase-immunoreactive cells in the locus coeruleus (LC). No significant difference was detected between these groups in the cross-sectional ar...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
Journal:
Neuropathology and applied neurobiology
Volume:
31
Issue:
2
Pages:
115-126
Publication date:
2005-04-05
DOI:
EISSN:
1365-2990
ISSN:
0305-1846
URN:
uuid:aa99ed2a-adbd-469b-91ed-238c1c047eb1
Source identifiers:
242717
Local pid:
pubs:242717

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