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Role of epididymal receptor HE6 in the regulation of sperm microenvironment.

Abstract:

HE6 (GPR64) is a highly conserved, tissue-specific heptahelical receptor of the human epididymis. The seven transmembrane (TM7) domains are a hallmark of G-protein-coupled receptors (GPCRs) which have a proven history of being excellent therapeutic targets. Of all currently marketed drugs, >30% are modulators of specific heptahelical receptors, emphasizing the potential of HE6 as a target for pharmaceutical intervention. Targeted mutation of the mouse HE6 counterpart resulted in male infer...

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Publisher copy:
10.1016/j.mce.2005.12.023

Authors


Kirchhoff, C More by this author
Obermann, H More by this author
Journal:
Molecular and cellular endocrinology
Volume:
250
Issue:
1-2
Pages:
43-48
Publication date:
2006-05-05
DOI:
EISSN:
1872-8057
ISSN:
0303-7207
URN:
uuid:aa978a7d-c4ff-4c50-95e7-69ebfb6b40bb
Source identifiers:
95880
Local pid:
pubs:95880

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