Journal article
Fibronectin III 13-14 domains induce joint damage via Toll-like receptor 4 activation and synergize with interleukin-1 and tumour necrosis factor.
- Abstract:
-
Cartilage loss is a feature of chronic arthritis. It results from degradation of the extracellular matrix which is composed predominantly of aggrecan and type II collagen. Extracellular matrix degradation is mediated by aggrecanases and matrix metalloproteinases (MMPs). Recently, a number of endogenous matrix molecules, including fibronectin (FN), have been implicated in mediating cartilage degradation. We were interested in studying the C-terminal heparin-binding region of FN since it mediat...
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- Publication status:
- Published
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- Publisher copy:
- 10.1159/000329632
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Bibliographic Details
- Journal:
- Journal of innate immunity
- Volume:
- 4
- Issue:
- 1
- Pages:
- 69-79
- Publication date:
- 2012-01-01
- DOI:
- EISSN:
-
1662-8128
- ISSN:
-
1662-811X
- Source identifiers:
-
229325
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:229325
- UUID:
-
uuid:aa9394ff-c732-4dda-8413-5162b962067b
- Local pid:
- pubs:229325
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2012
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