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Fibronectin III 13-14 domains induce joint damage via Toll-like receptor 4 activation and synergize with interleukin-1 and tumour necrosis factor.

Abstract:

Cartilage loss is a feature of chronic arthritis. It results from degradation of the extracellular matrix which is composed predominantly of aggrecan and type II collagen. Extracellular matrix degradation is mediated by aggrecanases and matrix metalloproteinases (MMPs). Recently, a number of endogenous matrix molecules, including fibronectin (FN), have been implicated in mediating cartilage degradation. We were interested in studying the C-terminal heparin-binding region of FN since it mediat...

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Publication status:
Published

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Publisher copy:
10.1159/000329632

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Journal of innate immunity
Volume:
4
Issue:
1
Pages:
69-79
Publication date:
2012-01-01
DOI:
EISSN:
1662-8128
ISSN:
1662-811X
Source identifiers:
229325

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