Journal article
Paclitaxel with or without trametinib or pazopanib in advanced wild-type BRAF Melanoma (PACMEL): a multicentre, open-label, randomised, controlled phase II trial
- Abstract:
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Backround: Advanced melanoma treatments often rely on immunotherapy or targeting mutations, with few treatment options for wild-type BRAF (BRAF-wt) melanoma. However, the MAPK pathway is activated in most melanoma, including BRAF-wt. We assessed whether inhibiting this pathway by adding kinase inhibitors trametinib or pazopanib to paclitaxel chemotherapy improved outcomes in patients with advanced BRAF-wt melanoma in a phase II, randomised, open-label trial.
Patients and Methods: P...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 208.9KB)
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- Publisher copy:
- 10.1093/annonc/mdy500
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Authors
Funding
+ National Institute of Health Research
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Funding agency for:
Middleton, M
Grant:
G0601617
GSK/Novartis
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National Cancer
Research Network
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University of Oxford
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Bibliographic Details
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Annals of Oncology Journal website
- Volume:
- 30
- Issue:
- 2
- Pages:
- 317–324
- Publication date:
- 2018-11-14
- Acceptance date:
- 2018-10-30
- DOI:
- EISSN:
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1569-8041
- ISSN:
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0923-7534
- Source identifiers:
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942833
Item Description
- Pubs id:
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pubs:942833
- UUID:
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uuid:aa8a31a4-139a-4f97-a8f6-792c7a7ffdba
- Local pid:
- pubs:942833
- Deposit date:
- 2018-11-16
Terms of use
- Copyright holder:
- Urbonas, et al
- Copyright date:
- 2018
- Notes:
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© The Author(s) 2018. Published by Oxford University Press on behalf of the European Society for Medical Oncology.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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