Combinations of CD45 isoforms are crucial for immune function and disease.

Journal article

Expression of the CD45 Ag in hemopoietic cells is essential for normal development and function of lymphocytes, and both mice and humans lacking expression exhibit SCID. Human genetic variants of CD45, the exon 4 C77G and exon 6 A138G alleles, which alter the pattern of CD45 isoform expression, are associated with autoimmune and infectious diseases. We constructed transgenic mice expressing either an altered level or combination of CD45 isoforms. We show that the total level of CD45 expressed...

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Authors: Dawes, R; Petrova, S; Liu, Z; Wraith, D; Beverley, P

• Journal: Journal of Immunology
• Volume: 176
• Issue: 6
• Pages: 3417-3425
• Publication date: 2006-03-01
• DOI: 10.4049/jimmunol.176.6.3417
• EISSN: 1550-6606
• ISSN: 0022-1767
• Language: English
• Keywords: Encephalomyelitis, Autoimmune, Experimental; T-Lymphocytes; Antigens, CD45; Cells, Cultured; Peptide Fragments; Myelin-Oligodendrocyte Glycoprotein; Mice; Lymphocyte Activation; Myelin Proteins; Cell Proliferation; Mice, Transgenic; Protein Isoforms; Myelin-Associated Glycoprotein; Animals; Cytokines