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Journal article

Combinations of CD45 isoforms are crucial for immune function and disease.

Abstract:

Expression of the CD45 Ag in hemopoietic cells is essential for normal development and function of lymphocytes, and both mice and humans lacking expression exhibit SCID. Human genetic variants of CD45, the exon 4 C77G and exon 6 A138G alleles, which alter the pattern of CD45 isoform expression, are associated with autoimmune and infectious diseases. We constructed transgenic mice expressing either an altered level or combination of CD45 isoforms. We show that the total level of CD45 expressed...

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Publisher copy:
10.4049/jimmunol.176.6.3417

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Journal:
Journal of Immunology More from this journal
Volume:
176
Issue:
6
Pages:
3417-3425
Publication date:
2006-03-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Language:
English
Keywords:
Pubs id:
pubs:33413
UUID:
uuid:aa798831-cf89-481c-b4c2-d19f23bf87dd
Local pid:
pubs:33413
Source identifiers:
33413
Deposit date:
2012-12-19

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