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IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis.

Abstract:

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract that is caused in part by a dysregulated immune response to the intestinal flora. The common interleukin (IL)-12/IL-23p40 subunit is thought to be critical for the pathogenesis of IBD. We have analyzed the role of IL-12 versus IL-23 in two models of Helicobacter hepaticus-triggered T cell-dependent colitis, one involving anti-IL-10R monoclonal antibody treatment of infected T cell-sufficient host...

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Publication status:
Published

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Publisher copy:
10.1084/jem.20061082

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Journal:
Journal of experimental medicine More from this journal
Volume:
203
Issue:
11
Pages:
2485-2494
Publication date:
2006-10-01
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
Language:
English
Keywords:
Pubs id:
pubs:8278
UUID:
uuid:aa6f60db-0b6f-49d5-92f2-278f19e9d0ad
Local pid:
pubs:8278
Source identifiers:
8278
Deposit date:
2012-12-19

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