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Early pathogenesis during infectious bursal disease in susceptible chickens is associated with changes in B cell genomic methylation and loss of genome integrity

Abstract:

We propose a model by which an increase in the genomic modification, 5-hydroxymethylcytosine (5hmC), contributes to B cell death within the chicken bursa of Fabricus (BF) infected with infectious bursal disease virus (IBDV). Our findings indicate that, following an IBDV infection, Rhode Island Red (RIR) chickens have fewer surviving B cells and higher levels of 5hmC in the BF than the more resistant 15l line of birds. Elevated genomic 5hmC levels within the RIR BF are associated with markers ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.dci.2017.03.014

Authors


Ciccone, NA More by this author
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Department:
Oxford, MPLS, Zoology
Broadbent, AJ More by this author
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Publisher:
Elsevier Publisher's website
Journal:
Developmental and Comparative Immunology Journal website
Volume:
73
Pages:
169-174
Publication date:
2017-03-18
Acceptance date:
2017-03-16
DOI:
EISSN:
1879-0089
ISSN:
0145-305X
Pubs id:
pubs:686768
URN:
uri:aa6d6176-8bad-4533-a413-eb8ebde44bf6
UUID:
uuid:aa6d6176-8bad-4533-a413-eb8ebde44bf6
Local pid:
pubs:686768

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