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Journal article

Impaired synaptic plasticity and motor learning in mice with a point mutation implicated in human speech deficits.

Abstract:

The most well-described example of an inherited speech and language disorder is that observed in the multigenerational KE family, caused by a heterozygous missense mutation in the FOXP2 gene. Affected individuals are characterized by deficits in the learning and production of complex orofacial motor sequences underlying fluent speech and display impaired linguistic processing for both spoken and written language. The FOXP2 transcription factor is highly similar in many vertebrate species, wit...

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Publication status:
Published

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Publisher copy:
10.1016/j.cub.2008.01.060

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Experimental Psychology
Role:
Author
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Journal:
Current biology : CB
Volume:
18
Issue:
5
Pages:
354-362
Publication date:
2008-03-01
DOI:
EISSN:
1879-0445
ISSN:
0960-9822
Source identifiers:
6355
Language:
English
Keywords:
Pubs id:
pubs:6355
UUID:
uuid:aa694c4a-a61b-4bdc-80af-a503cc259269
Local pid:
pubs:6355
Deposit date:
2012-12-19

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