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The human Holliday junction resolvase GEN1 rescues the meiotic phenotype of a Schizosaccharomyces pombe mus81 mutant.

Abstract:

A key step in meiotic recombination involves the nucleolytic resolution of Holliday junctions to generate crossovers. Although the enzyme that performs this function in human cells is presently unknown, recent studies led to the identification of the XPG-family endonuclease GEN1 that promotes Holliday junction resolution in vitro, suggesting that it may perform a related function in vivo. Here, we show that ectopic expression of GEN1 in fission yeast mus81Delta strains results in Holliday jun...

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Publication status:
Published

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Publisher copy:
10.1093/nar/gkp1179

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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Journal:
Nucleic acids research
Volume:
38
Issue:
6
Pages:
1866-1873
Publication date:
2010-04-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:aa64d273-789b-456f-bd29-1ddde5ba6182
Source identifiers:
100130
Local pid:
pubs:100130

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