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Journal article

BNIP3 expression is linked with hypoxia-regulated protein expression and with poor prognosis in non-small cell lung cancer.

Abstract:

BNIP3 is a proapoptotic protein regulated by hypoxia-inducible factor 1. We analyzed BNIP3 expression in 105 tumor samples from early operable, non-small lung cancer and the relationship of expression to hypoxia-inducible factor 1alpha, other hypoxia-regulated pathways, and prognosis. There was strong cytoplasmic expression in >10% of cells in 40 of 105 cases. BNIP3 expression was associated significantly with high hypoxia-inducible factor 1alpha (P = 0.003), carbonic anhydrase 9 (P = 0.04...

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Publication status:
Published

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Authors


Giatromanolaki, A More by this author
Koukourakis, MI More by this author
Sowter, HM More by this author
Sivridis, E More by this author
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Journal:
Clinical cancer research : an official journal of the American Association for Cancer Research
Volume:
10
Issue:
16
Pages:
5566-5571
Publication date:
2004-08-05
DOI:
EISSN:
1557-3265
ISSN:
1078-0432
URN:
uuid:aa5bd1af-f5ee-40f1-abf3-9e4419de2f46
Source identifiers:
119141
Local pid:
pubs:119141

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