Abnormalities or derangements of the orderly proliferation and cycling of cells is the quintessential definition of a cancer or malignant cell. The complex nature of the interaction of several interdependent cell cycle proteins has and continues to be unravelled. Key functions have been ascribed to many of the proteins and the delicate balance that maintains cell normal cell cycling is now understood. Within the cell cycle, the GI proteins have come under intense scrutiny, especially the inte...