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Journal article

Multivariate analysis of quantitative trait loci influencing variation in anxiety-related behavior in laboratory mice.

Abstract:

The number and mode of action of quantitative trait loci (QTL) that contribute to behavioral variation in rodents is still largely unknown. On theoretical grounds, multivariate techniques are expected to yield new insights into this problem, but there are only a few examples of its application in practice. Here we explore the power of multivariate approaches to uncover the genetic architecture of 23 anxiety-related phenotypes in 1636 F2 laboratory mice. We detected QTL with a genome-wide sign...

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Publication status:
Published

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Publisher copy:
10.1007/s00335-003-3032-y

Authors


DeFries, JC More by this author
Henderson, ND More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Journal:
Mammalian genome : official journal of the International Mammalian Genome Society
Volume:
15
Issue:
2
Pages:
69-76
Publication date:
2004-02-05
DOI:
EISSN:
1432-1777
ISSN:
0938-8990
URN:
uuid:aa56ff67-8929-4d83-a22b-8b0908c88073
Source identifiers:
32668
Local pid:
pubs:32668

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