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Fine-mapping of colorectal cancer susceptibility loci at 8q23.3, 16q22.1 and 19q13.11: refinement of association signals and use of in silico analysis to suggest functional variation and unexpected candidate target genes.

Abstract:

We have previously identified several colorectal cancer (CRC)-associated polymorphisms using genome-wide association (GWA) analysis. We sought to fine-map the location of the functional variants for three of these regions at 8q23.3 (EIF3H), 16q22.1 (CDH1/CDH3) and 19q13.11 (RHPN2). We genotyped two case-control sets at high density in the selected regions and used existing data from four other case-control sets, comprising a total of 9328 CRC cases and 10 480 controls. To improve marker densi...

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Publication status:
Published

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Publisher copy:
10.1093/hmg/ddr190

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
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Journal:
Human molecular genetics
Volume:
20
Issue:
14
Pages:
2879-2888
Publication date:
2011-07-01
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
Source identifiers:
138122
Language:
English
Keywords:
Pubs id:
pubs:138122
UUID:
uuid:aa55e5a9-e3f5-46e4-ac83-a824b983cb06
Local pid:
pubs:138122
Deposit date:
2012-12-19

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