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Journal article

Role of interleukin-1beta in postoperative cognitive dysfunction.

Abstract:

OBJECTIVE: Although postoperative cognitive dysfunction (POCD) often complicates recovery from major surgery, the pathogenic mechanisms remain unknown. We explored whether systemic inflammation, in response to surgical trauma, triggers hippocampal inflammation and subsequent memory impairment, in a mouse model of orthopedic surgery. METHODS: C57BL/6J, knock out (lacking interleukin [IL]-1 receptor, IL-1R(-/-)) and wild type mice underwent surgery of the tibia under general anesthesia. Separa...

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Publication status:
Published

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Publisher copy:
10.1002/ana.22082

Authors


Cibelli, M More by this author
Fidalgo, AR More by this author
Terrando, N More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, BHF Centre of Research Excellence
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Journal:
Annals of neurology
Volume:
68
Issue:
3
Pages:
360-368
Publication date:
2010-09-05
DOI:
EISSN:
1531-8249
ISSN:
0364-5134
URN:
uuid:aa5540c9-8388-44a8-b29e-303c7362cdb6
Source identifiers:
224492
Local pid:
pubs:224492

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