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Dynamic histone H3 methylation during gene induction: HYPB/Setd2 mediates all H3K36 trimethylation.

Abstract:

Understanding the function of histone modifications across inducible genes in mammalian cells requires quantitative, comparative analysis of their fate during gene activation and identification of enzymes responsible. We produced high-resolution comparative maps of the distribution and dynamics of H3K4me3, H3K36me3, H3K79me2 and H3K9ac across c-fos and c-jun upon gene induction in murine fibroblasts. In unstimulated cells, continuous turnover of H3K9 acetylation occurs on all K4-trimethylated...

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Publication status:
Published

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Publisher copy:
10.1038/sj.emboj.7601967

Authors


Edmunds, JW More by this author
Mahadevan, LC More by this author
Clayton, AL More by this author
Journal:
The EMBO journal
Volume:
27
Issue:
2
Pages:
406-420
Publication date:
2008-01-05
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
URN:
uuid:aa5316ee-d112-448e-8366-7ee2f0567169
Source identifiers:
202320
Local pid:
pubs:202320

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