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Interleukin 13 (IL-13)-regulated expression of the chondroprotective metalloproteinase ADAM15 is reduced in aging cartilage

Abstract:

Objective
The adamalysin metalloproteinase 15 (ADAM15) has been shown to protect against development of osteoarthritis in mice. Here, we have investigated factors that control ADAM15 levels in cartilage.
Design
Secretomes from wild-type and Adam15−/− chondrocytes were compared by label-free quantitative mass spectrometry. mRNA was isolated from murine knee joints, either with or without surgical induction of osteoarthritis on male C57BL/6 mice, and the expression of Adam15 and ot...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.ocarto.2020.100128

Authors


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Name:
Arthritis Research UK
Grant:
21621
20205
Publisher:
Elsevier
Journal:
Osteoarthritis and Cartilage Open More from this journal
Volume:
2
Issue:
4
Article number:
100128
Publication date:
2020-12-04
Acceptance date:
2020-12-01
DOI:
EISSN:
2665-9131
Pmid:
33381768
Language:
English
Keywords:
Pubs id:
1152303
Local pid:
pubs:1152303
Deposit date:
2021-01-20

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