Journal article
Interleukin 13 (IL-13)-regulated expression of the chondroprotective metalloproteinase ADAM15 is reduced in aging cartilage
- Abstract:
-
Objective
Expand abstract
The adamalysin metalloproteinase 15 (ADAM15) has been shown to protect against development of osteoarthritis in mice. Here, we have investigated factors that control ADAM15 levels in cartilage.
Design
Secretomes from wild-type and Adam15−/− chondrocytes were compared by label-free quantitative mass spectrometry. mRNA was isolated from murine knee joints, either with or without surgical induction of osteoarthritis on male C57BL/6 mice, and the expression of Adam15 and ot...
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
Versus Arthritis
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Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Osteoarthritis and Cartilage Open Journal website
- Volume:
- 2
- Issue:
- 4
- Article number:
- 100128
- Publication date:
- 2020-12-04
- Acceptance date:
- 2020-12-01
- DOI:
- EISSN:
-
2665-9131
- Pmid:
-
33381768
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1152303
- Local pid:
- pubs:1152303
- Deposit date:
- 2021-01-20
Terms of use
- Copyright holder:
- Osteoarthritis Research Society International
- Copyright date:
- 2020
- Rights statement:
- ©2020 Osteoarthritis Research Society International (OARSI). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license
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