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Acute effects of LI 160 (extract of Hypericum perforatum, St John's wort) and two of its constituents on neuroendocrine responses in the rat.

Abstract:

Extracts of Hypericum perforatum (St John's wort), such as LI 160, which are effective antidepressants have several active constituents. Their mode of action in depression, however, is unclear. In the present investigation, we assessed the effect of equivalent doses of LI 160 and two of its components, hypericin and hyperforin on serotonin (5-HT) and dopamine (DA)-mediated neuroendocrine responses in the rat. LI 160, hypericin and hyperforin significantly and equivalently increased plasma cor...

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Publication status:
Published

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Publisher copy:
10.1177/026988110001400404
Journal:
Journal of psychopharmacology (Oxford, England) More from this journal
Volume:
14
Issue:
4
Pages:
360-363
Publication date:
2000-01-01
DOI:
EISSN:
1461-7285
ISSN:
0269-8811
Language:
English
Keywords:
Pubs id:
pubs:185774
UUID:
uuid:aa44a057-bbba-4cf9-a811-0294b63c11ef
Local pid:
pubs:185774
Source identifiers:
185774
Deposit date:
2012-12-19

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