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A simian-adenovirus-vectored rabies vaccine suitable for thermostabilisation and clinical development for low-cost single-dose pre-exposure prophylaxis

Abstract:
Background Estimates of current global rabies mortality range from 26,000 to 59,000 deaths per annum. Although pre-exposure prophylaxis using inactivated rabies virus vaccines (IRVs) is effective, it requires two to three doses and is regarded as being too expensive and impractical for inclusion in routine childhood immunization programmes. Methodology/ Principal findings Here we report the development of a simian-adenovirus-vectored rabies vaccine intended ... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1371/journal.pntd.0006870

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Jenner Institute
Role:
Author
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Funding agency for:
Draper, SJ
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Funding agency for:
Draper, SJ
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Funding agency for:
Douglas, AD
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Neglected Tropical Diseases Journal website
Volume:
12
Issue:
10
Pages:
e0006870
Publication date:
2018-10-29
Acceptance date:
2018-09-24
DOI:
EISSN:
1935-2735
ISSN:
1935-2727
Pubs id:
pubs:935891
URN:
uri:aa41fd37-35d8-4b55-91ed-6882c95aeeee
UUID:
uuid:aa41fd37-35d8-4b55-91ed-6882c95aeeee
Local pid:
pubs:935891
Language:
English

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