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Journal article

Targeting MAPK (Ras/ERK) and PI3K/Akt pathways in pituitary tumorigenesis.

Abstract:

BACKGROUND: Pituitary adenomas are common intracranial neoplasms, comprising 10 - 15% of all brain tumors. Data from autopsy studies suggest that pituitary adenomas develop in 17 - 25% of the population. Nevertheless, the pathogenesis of sporadic pituitary tumors still remains obscure. OBJECTIVE: In this review, the roles of MAPK (mainly Ras/extracellular signal-regulated protein kinase (ERK)) and PI3K/Akt signaling pathways in pituitary tumorigenesis are summarised. METHODS: A full data sea...

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Publication status:
Published

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Publisher copy:
10.1517/14728220903170675

Authors


Journal:
Expert opinion on therapeutic targets
Volume:
13
Issue:
9
Pages:
1121-1134
Publication date:
2009-09-01
DOI:
EISSN:
1744-7631
ISSN:
1472-8222
Source identifiers:
138617
Language:
English
Keywords:
Pubs id:
pubs:138617
UUID:
uuid:aa39bc00-6dd0-4019-8a84-4044332f19f4
Local pid:
pubs:138617
Deposit date:
2012-12-19

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