Human brain weight is correlated with expression of the 'housekeeping genes' beta-2-microglobulin (β2M) and TATA-binding protein (TBP).

Journal article

AIMS: Many variables affect mRNA measurements in post mortem human brain tissue. Brain weight has not hitherto been considered to be such a factor. This study examined whether there is any relationship between brain weight and mRNA abundance. METHODS: We investigated quantitative real-time RT-PCR data for five 'housekeeping genes' using the 104 adult brains of the Stanley Microarray Consortium series. Eleven data sets were analysed, from cerebellum, hippocampus, and anterior cingulate cortex...

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Authors: Harrison, P; Laatikainen, L; Tunbridge, E; Eastwood, S

• Publication status: Published
• Journal: Neuropathology and applied neurobiology
• Volume: 36
• Issue: 6
• Pages: 498-504
• Publication date: 2010-10-01
• DOI: 10.1111/j.1365-2990.2010.01098.x
• EISSN: 1365-2990
• ISSN: 0305-1846
• Language: English
• Keywords: Reverse Transcriptase Polymerase Chain Reaction; TATA-Box Binding Protein; Humans; Organ Size; Adult; Female; Middle Aged; beta 2-Microglobulin; RNA, Messenger; Brain; Male