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Thesis

Functional genomics of ankylosing spondylitis

Abstract:

Ankylosing spondylitis (AS) is a chronic inflammatory arthritis primarily affecting the joints of the spine and pelvis. Its prevalence is highly correlated with the HLA-B*27 allele but not all of the genetic risk for this complex disease is explained by this association. At least 113 other susceptibility loci have been identified, with the NPEPPS locus implicated by multiple high impact studies.

This thesis aimed to fine-map the AS disease-associated signal that overlaps the NPEPP...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Research group:
Julian Knight Group
Oxford college:
Merton College
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Oxford college:
Merton College
Role:
Supervisor
ORCID:
0000-0002-0377-5536
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Oxford college:
Merton College
Role:
Supervisor
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Oxford college:
Merton College
Role:
Supervisor
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Oxford college:
Merton College
Role:
Supervisor

Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
University of Oxford

Language:
English
Keywords:
Deposit date:
2020-12-28

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