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Blocking porcine sialoadhesin improves extracorporeal porcine liver xenoperfusion with human blood.

Abstract:

BACKGROUND: Patients in fulminant hepatic failure currently do not have a temporary means of support while awaiting liver transplantation. A potential therapeutic approach for such patients is the use of extracorporeal perfusion with porcine livers as a form of "liver dialysis". During a 72-h extracorporeal perfusion of porcine livers with human blood, porcine Kupffer cells bind to and phagocytose human red blood cells (hRBC) causing the hematocrit to decrease to 2.5% of the original value. O...

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Publication status:
Published

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Publisher copy:
10.1111/xen.12043

Authors


Host title:
Xenotransplantation
Volume:
20
Issue:
4
Pages:
239-251
Publication date:
2013-01-01
Event location:
Denmark
DOI:
EISSN:
1399-3089
ISSN:
0908-665X
Keywords:
Pubs id:
pubs:146564
UUID:
uuid:aa2de77b-12d8-4e8e-963a-b1332a784c11
Local pid:
pubs:146564
Source identifiers:
146564
Deposit date:
2012-12-19

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