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Limited polymorphism in the dihydrofolate reductase (dhfr) and dihydropteroate synthase genes (dhps) of Plasmodium knowlesi isolate from Thailand

Abstract:

Background: The 2022 malaria WHO reported around 4000 P. knowlesi infections in the South-East Asia region. In the same period, 72 positive cases were reported by the Department of Disease Control in Thailand, suggesting a persistent infection. Little is known about dihydrofolate reductase (pkdhfr) and dihydropteroate synthase (pkdhps), putative antimalarial resistance markers for P. knowlesi. The relevant amplification and sequencing protocol are present...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.actatropica.2023.107016

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Grant:
106698/B/14/Z
220211/A/20/A


Publisher:
Elsevier
Journal:
Acta Tropica More from this journal
Volume:
248
Article number:
107016
Place of publication:
Netherlands
Publication date:
2023-09-07
Acceptance date:
2023-08-31
DOI:
ISSN:
0001-706X
Pmid:
37683820


Language:
English
Keywords:
Pubs id:
1529365
Local pid:
pubs:1529365
Deposit date:
2023-12-06

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