Immunological impact of an additional early measles vaccine in Gambian children: Responses to a boost at 3 years

Journal article

Background: Measles vaccine in early infancy followed by a dose at 9 months of age protects against measles and enhances child survival through non-specific effects. Little is known of immune responses in the short or long term after booster doses. Methods: Infants were randomized to receive measles vaccine at 9 months of age (group 1) or 4 and 9 months of age (group 2). Both groups received a boost at 36 months of age. T-cell effector and memory responses using IFN-γ ELIspot and cytokine ass...

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Authors: Njie-Jobe, J; Nyamweya, S; Miles, D; van der Sande, M; Zaman, S

• Journal: Vaccine
• Volume: 30
• Issue: 15
• Pages: 2543-2550
• Publication date: 2012-03-28
• DOI: 10.1016/j.vaccine.2012.01.083
• EISSN: 1873-2518
• ISSN: 0264-410X
• Language: English
• Keywords: Two-dose schedule; Antibody; Measles vaccine; Cellular immunity; Booster dose