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Increased heat shock protein 90 (hsp90) expression leads to increased apoptosis in the monoblastoid cell line U937 following induction with TNF-alpha and cycloheximide: a possible role in immunopathology.

Abstract:

In this study, we examined the hypothesis that heat shock proteins (hsp) (such as hsp72 and hsp90) are implicated in the regulation of forms of cell injury that lead to programmed cell death. The monoblastoid cell line U937 has been used as a model system. For hsp90, which is not heat inducible in this cell line, we used stable U937 transfectants that either hyperexpress or hypoexpress the protein. For hsp72 (which is reproducibly induced in all three cell lines to relatively high levels of e...

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Publication status:
Published

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Authors


Galea-Lauri, J More by this author
Richardson, AJ More by this author
Latchman, DS More by this author
Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
157
Issue:
9
Pages:
4109-4118
Publication date:
1996-11-05
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:aa167ed6-ad8a-4cc0-8950-a7fc27088797
Source identifiers:
466398
Local pid:
pubs:466398

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