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Metabolite ratios as potential biomarkers for type 2 diabetes: a DIRECT study.

Abstract:

Aims/hypothesis

Circulating metabolites have been shown to reflect metabolic changes during the development of type 2 diabetes. In this study we examined the association of metabolite levels and pairwise metabolite ratios with insulin responses after glucose, glucagon-like peptide-1 (GLP-1) and arginine stimulation. We then investigated if the identified metabolite ratios were associated with measures of OGTT-derived beta cell function and with prevalent and incident type 2 diabe...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1007/s00125-017-4436-7

Authors


More from this funder
Name:
Sixth Framework Programme
Grant:
036894
More from this funder
Name:
European Research Council
Grant:
230374
More from this funder
Name:
Seventh Framework Programme
Grant:
259679
More from this funder
Name:
Centre for Medical Systems Biology
More from this funder
Name:
Netherlands Consortium for Healthy Ageing
Publisher:
Springer
Journal:
Diabetologia More from this journal
Publication date:
2017-09-01
Acceptance date:
2017-07-28
DOI:
EISSN:
1432-0428
ISSN:
0012-186X
Pmid:
28936587
Language:
English
Keywords:
Pubs id:
pubs:732942
UUID:
uuid:aa138533-9ba1-47d7-94b5-fcecbecafde2
Local pid:
pubs:732942
Source identifiers:
732942
Deposit date:
2017-11-09

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