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Journal article

Very-low-density lipoprotein response element in the promoter region of the human plasminogen activator inhibitor-1 gene implicated in the impaired fibrinolysis of hypertriglyceridemia.

Abstract:

Hypertriglyceridemia and impaired fibrinolytic function are linked to coronary heart disease and other atherothrombotic disorders. Triglyceride-rich lipoproteins may attenuate fibrinolysis by increasing the plasma levels of plasminogen activator inhibitor-1 (PAI-1). Furthermore, a common 4/5 guanosine (4G/5G) polymorphism in the promoter region of the PAI-1 gene has been indicated to influence plasma PAI-1 activity and to be involved in an allele-specific response to triglycerides. Herein we ...

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Publication status:
Published

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Publisher copy:
10.1161/01.atv.18.1.20

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
Journal:
Arteriosclerosis, thrombosis, and vascular biology
Volume:
18
Issue:
1
Pages:
20-26
Publication date:
1998-01-01
DOI:
EISSN:
1524-4636
ISSN:
1079-5642
Source identifiers:
14857

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