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Adenovirus gene transfer causes inflammation in the brain.

Abstract:

We report that injecting an E1-deleted, non-replicating, human adenovirus type 5 vector into the brain leads to an inflammatory response. Much of this inflammation is induced directly by the virion particles themselves rather than through the expression of new proteins from the vector. The severity of inflammation was found to depend on the strain of inbred rat used: PVG rats have less inflammation than AO rats in response to a vector injection. Twelve hours after injection of adenovirus vect...

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Neuroscience More from this journal
Volume:
66
Issue:
4
Pages:
1015-1024
Publication date:
1995-06-01
DOI:
EISSN:
1873-7544
ISSN:
0306-4522
Language:
English
Keywords:
Pubs id:
pubs:113331
UUID:
uuid:aa10b157-2d51-44c7-9421-a0d0ff819fa8
Local pid:
pubs:113331
Source identifiers:
113331
Deposit date:
2013-11-17

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