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Thesis

The role of histone 3 lysine 27 trimethylation in thymic epithelial cell development and function

Abstract:

Thymic epithelial cells (TEC) create the unique environment for the selection of T cells that are tolerant to self but reactive to foreign antigens. For this purpose, TEC express an almost comprehensive repertoire of self-antigens, through a process referred to as promiscuous gene expression (PGE). The precise molecular mechanisms that account for PGE remain incompletely defined although a subset of promiscuously expressed genes rely for their efficient expression on the presence of t...

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Role:
Supervisor
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Grant:
P1SKP3_174877
Funding agency for:
Annina Graedel
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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