Thesis icon

Thesis

The role of histone 3 lysine 27 trimethylation in thymic epithelial cell development and function

Abstract:

Thymic epithelial cells (TEC) create the unique environment for the selection of T cells that are tolerant to self but reactive to foreign antigens. For this purpose, TEC express an almost comprehensive repertoire of self-antigens, through a process referred to as promiscuous gene expression (PGE). The precise molecular mechanisms that account for PGE remain incompletely defined although a subset of promiscuously expressed genes rely for their efficient expression on the presence of t...

Expand abstract

Actions


Authors


More by this author
Division:
MSD
Department:
Paediatrics
Role:
Author

Contributors

Role:
Supervisor
More from this funder
Funding agency for:
Graedel, A
Grant:
P1SKP3_174877
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:aa106554-b722-4bf3-9d27-d0bf15850947
Deposit date:
2019-06-18

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP