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Journal article

Fixation and spread of somatic mutations in adult human colonic epithelium

Abstract:

We investigated the means and timing by which mutations become fixed in the human colonic epithelium by visualizing somatic clones and mathematical inference. Fixation requires two sequential steps. First, one of approximately seven active stem cells residing within each colonic crypt has to be mutated. Second, the mutated stem cell has to replace neighbors to populate the entire crypt in a process that takes several years. Subsequent clonal expansion due to crypt fission is infrequent for ne...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1016/j.stem.2018.04.020

Authors


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Name:
Medical Research Council
Grant:
MC_UU_12025
More from this funder
Name:
Wellcome Trust Grant
Grant:
103805
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Name:
NIHR Cambridge Biomedical Research Centre
Publisher:
Elsevier
Journal:
Cell Stem Cell More from this journal
Volume:
22
Issue:
6
Pages:
909-918
Publication date:
2018-05-17
Acceptance date:
2018-04-23
DOI:
EISSN:
1875-9777
ISSN:
1934-5909
Pmid:
29779891
Language:
English
Keywords:
Pubs id:
pubs:853369
UUID:
uuid:aa0c8363-47c0-4fd2-ab05-8052792f365f
Local pid:
pubs:853369
Source identifiers:
853369
Deposit date:
2018-07-12

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