Journal article
Fixation and spread of somatic mutations in adult human colonic epithelium
- Abstract:
-
We investigated the means and timing by which mutations become fixed in the human colonic epithelium by visualizing somatic clones and mathematical inference. Fixation requires two sequential steps. First, one of approximately seven active stem cells residing within each colonic crypt has to be mutated. Second, the mutated stem cell has to replace neighbors to populate the entire crypt in a process that takes several years. Subsequent clonal expansion due to crypt fission is infrequent for ne...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
NIHR Cambridge Biomedical Research Centre
More from this funder
Cancer Research UK
More from this funder
University of East Anglia
More from this funder
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Cell Stem Cell Journal website
- Volume:
- 22
- Issue:
- 6
- Pages:
- 909-918
- Publication date:
- 2018-05-17
- Acceptance date:
- 2018-04-23
- DOI:
- EISSN:
-
1875-9777
- ISSN:
-
1934-5909
- Pmid:
-
29779891
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:853369
- UUID:
-
uuid:aa0c8363-47c0-4fd2-ab05-8052792f365f
- Local pid:
- pubs:853369
- Source identifiers:
-
853369
- Deposit date:
- 2018-07-12
Terms of use
- Copyright holder:
- Nicholson et al
- Copyright date:
- 2018
- Notes:
- © 2018 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license.
- Licence:
- CC Attribution (CC BY)
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record